As is known, autoimmunity is a phenomenon that underlies the pathogenesis of RA, so that individuals suffering from it have antibodies against a variety of antigens, among which are those directed against citrullinated amino acids.
These are generated by post translational action of the enzyme peptidylarginine deiminase, which deiminizes the arginine residues transforming them into citrulline. The anti CCP were described in 1998 by Schellekens, and so far filaggrin, fibrinogen and fibrin have been identified as citrullinated autoantigens https://foodsocietyx.com/keto-viante.
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